Design of the Fracture Intervention Trial

  title={Design of the Fracture Intervention Trial},
  author={Dennis M. Black and Theodore Reiss and Michael C. Nevitt and Jane A. Cauley and D M Karpf and Steve Cummings},
  journal={Osteoporosis International},
The Fracture Intervention Trial (FIT) is a randomized, double-masked, placebo-controlled trial designed to test the hypothesis that alendronate, an amino-bisphosphonate, will reduce the rate of fractures in women aged 55–80 years with low hip bone marrow density (<0.68 gm/cm2 at the femoral neck). It is being conducted at 11 clinical centers around the United States with a coordinating center at UC San Francisco. The goal was to randomize 6000 women. When recruitment was completed (in May 1993… CONTINUE READING


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