Design of small molecules targeting transcriptional activation by NF-κB: overview of recent advances.

Abstract

BACKGROUND The transcription factor NF-κB plays a central role in immune signaling and the inflammatory response. It also activates transcription of antiapoptotic factors in tumor cells, leading to enhanced cell survival. Because of the importance of NF-κB in inflammation and cancer, there is considerable interest in development of drugs that inhibit NF-κB… (More)
DOI: 10.1517/17460440903143739

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