Design of shRNA and miRNA for Delivery to the CNS.

  title={Design of shRNA and miRNA for Delivery to the CNS.},
  author={Gabriela Toro Cabrera and Christian M{\"u}ller},
  journal={Methods in molecular biology},
Neurologic diseases tend to target various areas of the central nervous system (CNS) and can therefore result in paralysis, dementia, and death. Neurodegenerative diseases distinguish themselves from other diseases by affecting nerve cells, which unlike many other cells in our body cannot regenerate when severely injured. The discovery of RNA interference (RNAi) has enabled scientist to design new therapeutic approaches based on specific gene silencing rather than the canonical gene therapy… CONTINUE READING
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