Design of serine protease inhibitors with conformation restricted by amino acid side-chain-side-chain CH/pie interaction.

Abstract

A novel type of conformationally restricted peptides with the structure of H-D-Xaa-Phe-NH-CH2-C6H5 has been developed as inhibitors of serine proteinase chymotrypsin. The D-Xaa-alkyl and Phe-phenyl groups resulted in a formation of the hydrophobic core due to the side-chain-side-chain CH/pie interaction. Their spatial proximity was evidenced by 400 MHz 1H… (More)

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Cite this paper

@article{Shimohigashi1999DesignOS, title={Design of serine protease inhibitors with conformation restricted by amino acid side-chain-side-chain CH/pie interaction.}, author={Yasuyuki Shimohigashi and Tadao Nose and Yuhki Yamauchi and Iori Maeda}, journal={Biopolymers}, year={1999}, volume={51 1}, pages={9-17} }