Design of sequence-specific DNA-binding molecules.

@article{Dervan1986DesignOS,
  title={Design of sequence-specific DNA-binding molecules.},
  author={Peter B. Dervan},
  journal={Science},
  year={1986},
  volume={232 4749},
  pages={
          464-71
        }
}
  • P. Dervan
  • Published 25 April 1986
  • Chemistry, Biology
  • Science
Base sequence information can be stored in the local structure of right-handed double-helical DNA (B-DNA). The question arises as to whether a set of rules for the three-dimensional readout of the B-DNA helix can be developed. This would allow the design of synthetic molecules that bind DNA of any specific sequence and site size. There are four stages of development for each new synthetic sequence-specific DNA-binding molecule: design, synthesis, testing for sequence specificity, and… 
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