Design of self-dispersible dry nanosuspension through wet milling and spray freeze-drying for poorly water-soluble drugs.

@article{Niwa2013DesignOS,
  title={Design of self-dispersible dry nanosuspension through wet milling and spray freeze-drying for poorly water-soluble drugs.},
  author={Toshiyuki Niwa and Kazumi Danjo},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2013},
  volume={50 3-4},
  pages={272-81}
}
The purpose of the present research is to establish a novel nanosizing technique starting from wet nano-milling, named "dry nanosuspension" technique for poorly water-soluble drugs. The spray freeze-drying (SFD) method was applied instead of the spray-drying one previously developed. Drug particles were milled in the aqueous solution of dispersing agents using an oscillating beads-milling apparatus. The milled nanosuspension was sprayed to the surface of liquid nitrogen, and the resultant iced… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…