Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling.

@article{Torheim2009DesignOP,
  title={Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling.},
  author={Eirik A Torheim and Elisabeth Jarnaess and Birgitte Lygren and Kjetil Task{\'e}n},
  journal={The Biochemical journal},
  year={2009},
  volume={424 1},
  pages={69-78}
}
We have reported previously the design of a RIAD (RI-anchoring disruptor) peptide that specifically displaces PKA (protein kinase A) type I from the AKAP (A-kinase-anchoring protein) ezrin, which is present in the immunological synapse of T-cells. This increases immune reactivity by reducing the threshold for activation and may prove a feasible approach for… CONTINUE READING