Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin.

Abstract

We report the solid-phase synthesis of 21 linear analogues of A and D, two nonselective antagonists of the vasopressor (V1) and antidiuretic (V2) responses to arginine vasopressin (AVP). A is Aaa-D-Tyr(Et)-Phe-Val-Asn-Abu-Pro-Arg-Arg-NH2 (where Aaa = adamantylacetyl at position 1). D is the des-Arg9 analogue of A. Nine new analogues of A (1-9) and 12 new… (More)

Topics

Cite this paper

@article{Manning1990DesignOP, title={Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin.}, author={Martin Manning and Stoytcho Stoev and Andrzej Kolodziejczyk and Wieslaw A Klis and Marian Kruszynski and Aleksandra Misicka and Aleksandra Olma and Nga Ching Wo and William Sawyer}, journal={Journal of medicinal chemistry}, year={1990}, volume={33 11}, pages={3079-86} }