Design of polyamine-based therapeutic agents: new targets and new directions.

Abstract

Enzymes in the biosynthetic and catabolic polyamine pathway have long been considered targets for drug development, and early drug discovery efforts in the polyamine area focused on the design and development of specific inhibitors of the biosynthetic pathway, or polyamine analogues that specifically bind DNA. More recently, it has become clear that the… (More)
DOI: 10.1042/bse0460006

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