Design of peptide standards with the same composition and minimal sequence variation to monitor performance/selectivity of reversed-phase matrices.

@article{Mant2012DesignOP,
  title={Design of peptide standards with the same composition and minimal sequence variation to monitor performance/selectivity of reversed-phase matrices.},
  author={Colin T. Mant and Robert S. Hodges},
  journal={Journal of chromatography. A},
  year={2012},
  volume={1230},
  pages={
          30-40
        }
}
The present manuscript extends our de novo peptide design approach to the synthesis and evaluation of a new generation of reversed-phase HPLC peptide standards with the same composition and minimal sequence variation (SCMSV). Thus, we have designed and synthesized four series of peptide standards with the sequences Gly-X-Leu-Gly-Leu-Ala-Leu-Gly-Gly-Leu-Lys-Lys-amide, where the N-terminal is either N(α)-acetylated (Series 1) or contains a free α-amino group (Series 3); and Gly-Gly-Leu-Gly-Gly… CONTINUE READING
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