Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.

@article{Scrocchi2002DesignOP,
  title={Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis.},
  author={Louise A. Scrocchi and Yan Hong Chen and Stefko Waschuk and Feng Wang and Sindy Cheung and Audrey A Darabie and JoAnne McLaurin and Paul E. Fraser},
  journal={Journal of molecular biology},
  year={2002},
  volume={318 3},
  pages={697-706}
}
Human islet amyloid polypeptide (IAPP) is the major component of amyloid deposits found in the pancreas of over 90% of all cases of type-2 diabetes. We have generated a series of overlapping hexapeptides to target an amyloidogenic region of IAPP (residues 20-29) and examined their effects on fibril assembly. Peptide fragments corresponding to SNNFGA (residues 20-25) and GAILSST (residues 24-29) were strong inhibitors of the beta-sheet transition and amyloid aggregation. Circular dichroism… CONTINUE READING