Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20.

@article{Izumi2009DesignOP,
  title={Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20.},
  author={Kazuki Izumi and Eiichi N. Kodama and Kazuya Shimura and Yasuko Sakagami and Kentaro Watanabe and Saori Ito and Tsuyoshi Watabe and Yukihiro Terakawa and Hiroki Nishikawa and Stefan G. Sarafianos and Kazuo Kitaura and Shinya Oishi and Nobutaka Fujii and Masao Matsuoka},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 8},
  pages={4914-20}
}
Enfuvirtide (T-20) is a fusion inhibitor that suppresses replication of human immunodeficiency virus (HIV) variants with multi-drug resistance to reverse transcriptase and protease inhibitors. It is a peptide derived from the C-terminal heptad repeat (C-HR) of HIV-1 gp41, and it prevents interactions between the C-HR and the N-terminal HR (N-HR) of gp41, thus interfering with conformational changes that are required for viral fusion. However, prolonged therapies with T-20 result in the… CONTINUE READING

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