Design of on-target FAAH inhibitors.

@article{Deutsch2005DesignOO,
  title={Design of on-target FAAH inhibitors.},
  author={Dale G. Deutsch},
  journal={Chemistry & biology},
  year={2005},
  volume={12 11},
  pages={
          1157-8
        }
}
In this issue of Chemistry & Biology, Alexander and Cravatt propose a model for the binding of carbamate inhibitors to fatty acid amide hydrolase (FAAH), the enzyme that breaks down signaling lipids. Using competitive activity-based protein profiling and click chemistry, they designed potent and selective FAAH inhibitors and characterized their off-target reactions. 
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Prostaglandins Leukot. Essent

A. Fontana, V. Di Marzo, H. Cadas, D. Piomelli
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