Design of novel bicyclic analogues derived from a potent oxytocin antagonist.

@article{Flouret2006DesignON,
  title={Design of novel bicyclic analogues derived from a potent oxytocin antagonist.},
  author={George Flouret and Olivier Chaloin and Lenka Borovi{\vc}kov{\'a} and Jiřina Slaninov{\'a}},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2006},
  volume={12 6},
  pages={412-9}
}
Eleven new analogues were synthesized by modification of the potent oxytocin antagonist (OTA) [(S)Pmp(1), D-Trp(2), Pen(6), Arg(8)]-Oxytocin, or PA (parent antagonist), in which (S)Pmp = beta,beta-(3-thiapentamethylene)-beta-mercapto-propionic acid. By internal acylation of Lys, Orn, L-1,4-diaminobutyric acid (Dab), L-1,3-diaminopropionic acid (Dap) at… CONTINUE READING