Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

  title={Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.},
  author={Katrin Groebke Zbinden and Lilli Anselm and David W. Banner and J. Benz and Francesca Blasco and Guillaume D{\'e}coret and Jacques Himber and Bernd Kuhn and Narendra Panday and Fabienne Ricklin and Philippe Risch and Daniel Schlatter and Martin Stahl and Stefan Thomi and Robert Unger and Wolfgang Haap},
  journal={European journal of medicinal chemistry},
  volume={44 7},
Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed. 

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