Design of multifunctional non-viral gene vectors to overcome physiological barriers: dilemmas and strategies.

@article{Wang2012DesignOM,
  title={Design of multifunctional non-viral gene vectors to overcome physiological barriers: dilemmas and strategies.},
  author={Tao Wang and Jaydev Upponi and Vladimir Torchilin},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={427 1},
  pages={3-20}
}
Gene-based therapeutics hold great promise for medical advancement and have been used to treat various human diseases with mixed success. However, their therapeutic application in vivo is limited due largely to several physiological barriers. The design of non-viral gene vectors with the ability to overcome delivery obstacles is currently under extensive investigation. These efforts have placed an emphasis on the development of multifunctional vectors able to execute multiple tasks to… CONTINUE READING

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