Design of luminescent biochips based on enzyme, antibody, or DNA composite layers

@article{Marquette2003DesignOL,
  title={Design of luminescent biochips based on enzyme, antibody, or DNA composite layers},
  author={C. Marquette and D. Thomas and A. Degiuli and L. Blum},
  journal={Analytical and Bioanalytical Chemistry},
  year={2003},
  volume={377},
  pages={922-928}
}
  • C. Marquette, D. Thomas, +1 author L. Blum
  • Published 2003
  • Chemistry, Medicine
  • Analytical and Bioanalytical Chemistry
  • The use of beads bearing bioactive molecules to develop generic biochips based on chemi- and electro-chemiluminescent detection was evaluated. The biochips were composed of arrayed biosensors, including enzyme-charged beads, antigen-charged beads, or oligonucleotide-charged beads, entrapped in poly(vinyl alcohol) (PVA-SbQ) photopolymer. In each case the sensing layers were spotted at the surface of a glassy carbon electrode as 0.3 µL drops, generating 500–800 µm spots. The luminescent reactions… CONTINUE READING
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