Design of liposomal aerosols for improved delivery of rifampicin to alveolar macrophages.

@article{Vyas2004DesignOL,
  title={Design of liposomal aerosols for improved delivery of rifampicin to alveolar macrophages.},
  author={Suresh Prasad Vyas and Meganathan Kannan and Sanyog Jain and Vivek Mishra and Paramjit Singh},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={269 1},
  pages={37-49}
}
The present study was aimed at preparation, characterization, and performance evaluation of rifampicin-loaded aerosolized liposomes for their selective presentation to alveolar macrophages, that being the most dense site of tuberculosis infection. Egg phosphatidylcholine (PC)- and cholesterol (Chol)-based liposomes were modified by imparting negative charge (using dicetylphosphate, DCP) or by coating them with alveolar macrophage-specific ligands (maleylated bovine serum albumin, MBSA; and O… CONTINUE READING
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