Design of inhibitors of the HIV-1 integrase core domain using virtual screening

@article{Regon2014DesignOI,
  title={Design of inhibitors of the HIV-1 integrase core domain using virtual screening},
  author={Preetom Regon and Dhrubajyoti Gogoi and A. Rai and M. Bordoloi and R. L. Bezbaruah},
  journal={Bioinformation},
  year={2014},
  volume={10},
  pages={76 - 80}
}
Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). The integrase (IN) enzyme of HIV interacts with several cellular and viral proteins during the integration process. Thus, it represents an appropriate target for antiretroviral drugs (ARVs). We performed virtual screening of database compounds and designed analogues using Elvitegravir (EVG) as a standard compound. The 378 screened compounds were retrieved from ZINC… Expand
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