Design of humanized antibodies: from anti-Tac to Zenapax.

  title={Design of humanized antibodies: from anti-Tac to Zenapax.},
  author={Naoya Tsurushita and Paul R Hinton and Shankar Kumar},
  volume={36 1},
Since the introduction of hybridoma technology, monoclonal antibodies have become one of the most important tools in the biosciences, finding diverse applications including their use in the therapy of human disease. Initial attempts to use monoclonal antibodies as therapeutics were hampered, however, by the potent immunogenicity of mouse (and other rodent) antibodies in humans. Humanization technology has made it possible to remove the immunogenicity associated with the use of rodent antibodies… CONTINUE READING

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