Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors.

@article{Przydzial2005DesignOH,
  title={Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors.},
  author={Magdalena Przydzial and Irina D. Pogozheva and Jeffrey C.W. Ho and Kelly E. Bosse and E Sawyer and John R. Traynor and Henry I. Mosberg},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={2005},
  volume={66 5},
  pages={255-62}
}
Using results from our previously reported cyclic opioid peptide series and reliable models for mu-, delta-, and kappa-opioid receptors (MOR, DOR, and KOR, respectively) and their complexes with peptide ligands, we have designed and synthesized a series of cyclic pentapeptides of structure Tyr-C[D-Cys-Phe-Phe-X]-NH2, cyclized via disulfide, methylene, or ethylene dithioethers, and where X = D- or L-Cys; or D- or L-penicillamine (Pen; beta,beta-dimethylcysteine). Determination of binding… CONTINUE READING