Design of gefitinib-loaded poly (l-lactic acid) microspheres via a supercritical anti-solvent process for dry powder inhalation.

@article{Lin2017DesignOG,
  title={Design of gefitinib-loaded poly (l-lactic acid) microspheres via a supercritical anti-solvent process for dry powder inhalation.},
  author={Qing Lin and Guijin Liu and Ziyi Zhao and Dongwei Wei and Jiafeng Pang and Yanbin Jiang},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={532 1},
  pages={573-580}
}
To develop a safer, more stable and potent formulation of gefitinib (GFB), micro-spheres of GFB encapsulated into poly (l-lactic acid) (PLLA) have been prepared by supercritical anti-solvent (SAS) technology in this study. Operating factors were optimized using a selected OA16 (45) orthogonal array design, and the properties of the raw material and SAS processed samples were characterized by different methods The results show that the GFB-loaded PLLA particles prepared were spherical, having a… CONTINUE READING