Design of experiments: an efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry.

@article{Gullberg2004DesignOE,
  title={Design of experiments: an efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry.},
  author={Jonas Gullberg and P{\"a}r Jonsson and Anders Nordstr{\"o}m and Michael Sj{\"o}str{\"o}m and Thomas Moritz},
  journal={Analytical biochemistry},
  year={2004},
  volume={331 2},
  pages={283-95}
}
The usual aim in metabolomic studies is to quantify the entire metabolome of each of a series of biological samples. To do this for complex biological matrices, e.g., plant tissues, efficient and reproducible extraction protocols must be developed. However, derivatization protocols must also be developed if GC/MS (one of the mostly widely used analytical methods for metabolomics) is involved. The aim of this study was to investigate how different chemical and physical factors (extraction… CONTINUE READING

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