Design of culture substrates for large-scale expansion of neural stem cells.

@article{Konagaya2011DesignOC,
  title={Design of culture substrates for large-scale expansion of neural stem cells.},
  author={Shuhei Konagaya and Koichi Kato and Tadashi Nakaji-Hirabayashi and Hiroo Iwata},
  journal={Biomaterials},
  year={2011},
  volume={32 4},
  pages={
          992-1001
        }
}
Neural stem cells (NSCs) have been frequently used to investigate in vitro the molecular and cellular mechanisms underlying the development of the central nervous system (CNS). In addition, NSCs are regarded as one of the potential sources for the cell replacement therapy of CNS disorders. Most of these studies have utilized NSCs prepared by neurosphere culture. However, this method normally yields a heterogeneous population containing differentiated neural cells as well as NSCs. In addition… CONTINUE READING
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