Design of aromatic-containing cell-penetrating peptide mimics with structurally modified π electronics.

@article{Deronde2015DesignOA,
  title={Design of aromatic-containing cell-penetrating peptide mimics with structurally modified π electronics.},
  author={Brittany M Deronde and Alexander Birke and Gregory N Tew},
  journal={Chemistry},
  year={2015},
  volume={21 7},
  pages={3013-9}
}
Cell-penetrating peptides (CPPs) and their synthetic mimics (CPPMs) represent a class of molecules that facilitate the intracellular delivery of various cargo. Previous studies indicated that the presence of aromatic functionalities improved CPPM activity. Given that aromatic functionalities play prominent roles in membrane biology and participate in various π interactions, we explored whether these interactions could be optimized for improved CPPM activity. CPPMs were synthesized by ring… CONTINUE READING

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