Design of antiandrogens and their mechanisms of action: a case study (anandron).

  title={Design of antiandrogens and their mechanisms of action: a case study (anandron).},
  author={Jean Pierre Raynaud and Jean Fiet and J.-M. Le Goff and P. M. Martin and Martine Moguilewsky and Tiiu Ojasoo},
  journal={Hormone research},
  volume={28 2-4},
The design of a new drug is conditioned by knowledge of the biochemical mechanisms involved in the etiology of the disease to be treated. With regard to endocrine pathologies, such knowledge can be obtained in the clinic from systematic assays of urinary and plasma hormones, enzyme activities and target tissue receptor concentrations. The present paper describes the results of our assays of plasma 3 alpha-androstanediol glucuronide, 5 alpha-reductase and androgen receptor in prostate cancer… Expand
Chapter 21. New Horizons in the Treatment of Proliferative Prostatic Disease
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Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase?
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Nilutamide: An Antiandrogen for the Treatment of Prostate Cancer
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Non-michaelian behavior of 5α-reductase in human prostate
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Synthetic progestins are used in different types of cancer and hormonal replacement therapy, and in recent studies they have been linked to DNA adduct formation in steroid therapies. The purpose ofExpand
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Pathological and morphometric assessment of testicular parameters in patients with metastatic prostate cancer following treatment with either the antiandrogen Casodex (ZM176,334) or bilateral orchidectomy
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Multivariate analysis of plasma hormones in patients with metastatic prostate cancer receiving combined LHRH‐analog and antiandrogen therapy
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In summary, Win 49,596 produced a dose‐dependent suppression of BUG development in vitro, and was not androgenic. Expand