Design of an optimal Chebyshev-expanded discrimination function for globular proteins.

Abstract

We describe the construction of a scoring function designed to model the free energy of protein folding. An optimization technique is used to determine the best functional forms of the hydrophobic, residue-residue and hydrogen-bonding components of the potential. The scoring function is expanded by use of Chebyshev polynomials, the coefficients of which are… (More)

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Cite this paper

@article{Fain2002DesignOA, title={Design of an optimal Chebyshev-expanded discrimination function for globular proteins.}, author={Boris Fain and Yu Xia and Michael Levitt}, journal={Protein science : a publication of the Protein Society}, year={2002}, volume={11 8}, pages={2010-21} }