Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells.

@article{Zhang2011DesignOA,
  title={Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells.},
  author={Wei Zhang and Jingjing Song and Bangzhi Zhang and Liwei Liu and Kairong Wang and Rui Wang},
  journal={Bioconjugate chemistry},
  year={2011},
  volume={22 7},
  pages={1410-5}
}
TP10-5 (TK) was screened as the most promising candidate among the designed analogues of transportan 10 (TP10), a cell penetrating peptide (CPP) with remarkable capacity for membrane translocation. However, low levels of specificity and high toxicity limit its successful use for drug delivery applications. Here, we developed a new type of acid-activated CPP (TH) by replacement of all lysines of TK with histidines. As expected, histidine-containing TH can be activated and subsequently enter… CONTINUE READING
19 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…