Design of a rate- and time-programming drug release device using a hydrogel: pulsatile drug release from kappa-carrageenan hydrogel device by surface erosion of the hydrogel.

@article{Makino2001DesignOA,
  title={Design of a rate- and time-programming drug release device using a hydrogel: pulsatile drug release from kappa-carrageenan hydrogel device by surface erosion of the hydrogel.},
  author={K. Makino and R Idenuma and Takuya Murakami and Hiroyuki Ohshima},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2001},
  volume={20 4},
  pages={355-359}
}
We have found that a repetitive pulsatile drug release with a certain time interval is observed from a monolithic hydrogel device by surface erosion of the hydrogel. As a model system of pulsatile drug release, dibucaine hydrochloride and kappa-carrageenan hydrogel were chosen as a drug and a device, respectively. Electrostatic interactions between… CONTINUE READING