Design of a multiple slice interface chamber and application for resolving the temporal pattern of CREB phosphorylation in hippocampal long-term potentiation.

@article{Matthies1997DesignOA,
  title={Design of a multiple slice interface chamber and application for resolving the temporal pattern of CREB phosphorylation in hippocampal long-term potentiation.},
  author={Hansj{\"u}rgen Matthies and Stephanie M Schulz and Werner Thiemann and H. Siemer and Helmut Schmidt and Manfred Krug and Volker Hoellt},
  journal={Journal of neuroscience methods},
  year={1997},
  volume={78 1-2},
  pages={173-9}
}
We describe an improved method for the investigation of time-dependent intracellular events giving rise to long-lasting changes in synaptic efficacy. A new interface chamber for the simultaneous superfusion of approximately 30 rat hippocampal slices was designed. The slice chamber contains an upper and a lower medium reservoir connected by a grooved incubation platform which is mounted at an angle of 7 degrees on a thermoregulation unit. Surface slices placed in the chamber are perfused with… CONTINUE READING

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