Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells.


Some cancers, like acute myeloid leukemia (AML), use reactive oxygen species to endogenously activate cell proliferation and angiogenic signaling cascades. Thus many cancers display increases in reactive oxygen like hydrogen peroxide concentrations. To translate this finding into a therapeutic strategy we designed new hydrogen peroxide-activated agents with… (More)
DOI: 10.1016/j.bmc.2014.10.029


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