Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging

  title={Design of a head coil for high resolution mouse brain perfusion imaging using magnetic particle imaging},
  author={Matthias Graeser and Peter Ludewig and Patryk Szwargulski and Fynn Foerger and Tom Liebing and Nils Daniel Forkert and Florian Thieben and Tim Magnus and Tobias Knopp},
  journal={Physics in Medicine \& Biology},
Magnetic particle imaging (MPI) is a novel and versatile imaging modality developing toward human application. When up-scaling to human size, the sensitivity of the systems naturally drops as the coil sensitivity depends on the bore diameter. Thus, new methods to push the sensitivity limit further have to be investigated to cope for this loss. In this paper a dedicated surface coil for mice is developed, improving the sensitivity in cerebral imaging applications. Similar to magnetic resonance… 

Frequency-selective signal enhancement by a passive dual coil resonator for magnetic particle imaging

Objective. Magnetic particle imaging (MPI) visualizes the spatial distribution of magnetic nanoparticles. MPI already provides excellent temporal and good spatial resolution, however, to achieve

Magnetic particle imaging for assessment of cerebral perfusion and ischemia.

A basic introduction to MPI is provided, its current use for stroke imaging is discussed, and future applications are addressed, including the potential for clinical implementation.

System Matrix Based Reconstruction for Pulsed Sequences in Magnetic Particle Imaging

Improving resolution and sensitivity will widen possible medical applications of magnetic particle imaging. Pulsed excitation promises such benefits, at the cost of more complex hardware solutions

On the Receive Path Calibration of Magnetic Particle Imaging Systems

Magnetic nanoparticles are a valuable tool in many biomedical applications and can be used for diagnostic and therapeutic purposes. In magnetic particle imaging (MPI) and magnetic particle

Evidence that SPIO Chain Formation is Essential for High-Resolution MPI

Magnetic Particle Imaging (MPI) is a noninvasive imaging modality that exploits the saturation properties of superparamagnetic iron oxide particles (SPIOs). A major thrust of MPI research aims to

Implementation of the surface gradiometer receive coils for the improved detection limit and sensitivity in the single-sided MPI scanner

Objective. Magnetic Particle Imaging (MPI) promises to enhance diagnostic capabilities of the existing clinical imaging modalities. Traditional MPI scanners utilize cylindrical bore geometry that

Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging

Magnetic particle imaging (MPI) is a radiation-free vessel- and target-imaging modality that can sensitively detect nanoparticles. A static magnetic gradient field, referred to as a selection field,

Magnetic particle imaging



Human-sized magnetic particle imaging for brain applications

A human-sized MPI device with low technical requirements designed for detection of brain ischemia is presented, which opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.

Characterizing a Preclinical Magnetic Particle Imaging System With Separate Pickup Coil

This work presents initial results obtained from a prototype signal acquisition instrument designed to offer improvements to the sensitivity, and signal-to-noise ratio (SNR), of a preclinical MPI system (Bruker 25/20).

Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil

This work presents a highly sensitive gradiometric receive-coil unit combined with a noise-matching network tailored for the imaging of mice and proposes guidelines to improve the comparability of future MPI studies.

Magnetic Particle Imaging for Real-Time Perfusion Imaging in Acute Stroke.

For the first time, it is shown that MPI could be used as a diagnostic tool for relevant diseases in vivo, such as an ischemic stroke, due to its shorter image acquisition times and increased temporal resolution compared to that of MRI or CT.

Tomographic imaging using the nonlinear response of magnetic particles

A method for obtaining a high-resolution image of magnetic tracers that takes advantage of the nonlinear magnetization curve of small magnetic particles and has the potential to be developed into an imaging method characterized by both high spatial resolution as well as high sensitivity.

System Characterization of a Highly Integrated Preclinical Hybrid MPI-MRI Scanner

The feasibility of a highly integrated MPI-MRI hybrid systems has been proven successfully and will enable dual-modal in vivo preclinical investigations of mice and rats with high confidence of success, offering the unique feature of precise MPI FOV planning on the basis of MRI data and vice versa.

System calibration unit for magnetic particle imaging: System matrix

Magnetic particle imaging (MPI) has the potential to deliver images at high time resolution and submillimetre spatial resolution. In order to reconstruct the images from the measured data one needs

Hybrid system calibration for multidimensional magnetic particle imaging

In this work, the system matrix is determined by a hybrid approach and a new approach is introduced to address the background signal in image reconstruction, showing that this approach reduces artefacts in the reconstructed images.

Towards quantitative magnetic particle imaging: A comparison with magnetic particle spectroscopy

Magnetic Particle Imaging (MPI) is a quantitative imaging modality with promising features for several biomedical applications. Here, we study quantitatively the raw data obtained during MPI

Magnetic Particle Imaging: A Resovist Based Marking Technology for Guide Wires and Catheters for Vascular Interventions

A Ferucarbotran-based SPIO-varnish was developed and applied to a commercially available guidewire and diagnostic catheter for vascular interventional purposes and proved to be mechanically and chemically stable and thin enough to ensure normal handling as with uncoated devices.