Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering.

@article{Lee2012DesignOA,
  title={Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering.},
  author={Sang-chul Lee and Keunwan Park and Jieun Han and Joong-jae Lee and Hyun Jung Kim and Seungpyo Hong and Woosung Heu and Yu Jung Kim and Jae-Seok Ha and Seung Goo Lee and H K Cheong and Young Ho Jeon and Dongsup Kim and Hak-Sung Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 9},
  pages={3299-304}
}
Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-rich repeat modules in jawless… CONTINUE READING