Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer.

@article{Cao2016DesignOS,
  title={Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer.},
  author={Yu J Cao and D. Rodgers and Juanjuan Du and Insha Ahmad and Eric N. Hampton and Jennifer S. Y. Ma and Magdalena Mazagova and S. Choi and Hwayoung Yun and Han Xiao and Pengyu Yang and Xiaozhou Luo and Reyna K V Lim and H. Pugh and F. Wang and Stephanie A. Kazane and T. Wright and Chan Hyuk Kim and P. Schultz and T. Young},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 26},
  pages={
          7520-4
        }
}
Chimeric antigen receptor T (CAR-T) cells have demonstrated promising results against hematological malignancies, but have encountered significant challenges in translation to solid tumors. To overcome these hurdles, we have developed a switchable CAR-T cell platform in which the activity of the engineered cell is controlled by dosage of an antibody-based switch. Herein, we apply this approach to Her2-expressing breast cancers by engineering switch molecules through site-specific incorporation… Expand
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