Design of Protein Cores by Screening Combinatorial Sequence Library.

@article{Ye1998DesignOP,
  title={Design of Protein Cores by Screening Combinatorial Sequence Library.},
  author={Yu-Zhen Ye and H Tang and Da-fu Ding},
  journal={Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica},
  year={1998},
  volume={30 5},
  pages={525-539}
}
We have developed a new method, heterogeneous self-consistent ensemble optimization (hetero-SCEO), to select appropriate hydrophobic cores of proteins. It has been tested with five kinds of proteins: lambda-repressor, phage 434 CRO protein, interleukin-4, thioredoxin and ubiquitin. The results show that the method can be used for the de novo desigh of the… CONTINUE READING