Design of New Uracil Derivatives Possessing Inhibitory Activity with Respect to Reverse Transcriptase of HIV-1 Mutant K103N/Y181C


New highly active N 1-substituted uracil derivatives of the HIV-1 nonnucleoside reverse transcriptase inhibitor class were designed. The structure—activity relationship provided a basis for building a computer model of the inhibitory activity against reverse transcriptase of HIV-1 mutant K103N/Y181C. New compounds that were more active than nevirapine were… (More)
DOI: 10.1007/s11094-016-1353-x


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