Design of New Antimicrobial Peptides (AMPs) with “Specificity Determinants” that Encode Selectivity for Gram Negative Pathogens and Remove Both Gram-Positive Activity and Hemolytic Activity from Broad-spectrum AMPs

@inproceedings{Jiang2015DesignON,
  title={Design of New Antimicrobial Peptides (AMPs) with “Specificity Determinants” that Encode Selectivity for Gram Negative Pathogens and Remove Both Gram-Positive Activity and Hemolytic Activity from Broad-spectrum AMPs},
  author={Ziqing Jiang and Lajos Gera and Colin T. Mant and Robert S. Hodges},
  year={2015}
}
Antimicrobial peptides (AMPs) are widely distributed in nature, generally have broad-spectrum activity and represent a promising class of new antimicrobial agents. However, it is widely accepted that native AMPs lack specificity and may be too toxic (ability to lyse mammalian cells, normally expressed as hemolytic activity against human red blood cells) to be used for systemic treatment [1,2]. To overcome this problem, we developed the design concept of “specificity determinants” which refers… Expand

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