Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

@inproceedings{Kasheverov2011DesignON,
  title={Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds},
  author={I. E. Kasheverov and Maxim N. Zhmak and Alexey Yu Khruschov and V. I. Tsetlin},
  booktitle={Marine drugs},
  year={2011}
}
A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica. Based on computer modeling and the X-ray structure of the A. californica AChBP complex with the PnIA[A10L, D14K] analog, single and multiple amino acid substitutions were introduced in α-conotoxin PnIA aimed at compounds of higher affinity and… CONTINUE READING

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