Design of Catalytically Amplified Sensors for Small Molecules

@inproceedings{Makhlynets2014DesignOC,
  title={Design of Catalytically Amplified Sensors for Small Molecules},
  author={Olga V Makhlynets and Ivan V Korendovych},
  booktitle={Biomolecules},
  year={2014}
}
Catalytically amplified sensors link an allosteric analyte binding site with a reactive site to catalytically convert substrate into colored or fluorescent product that can be easily measured. Such an arrangement greatly improves a sensor's detection limit as illustrated by successful application of ELISA-based approaches. The ability to engineer synthetic… CONTINUE READING