Design of β-turn Based Therapeutic Agents

  title={Design of β-turn Based Therapeutic Agents},
  author={K. Kee Suat and Seetharama D.S. Jois},
Peptides and proteins are essential to many biological processes. The interaction between the peptide ligands and their receptor targets commonly involves β-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus, there has been a great deal of interest in the design of peptidomimetics (modified peptides) as therapeutic agents by mimicking β-turn structures. This review highlights the importance of β-turn in the… CONTINUE READING