Design issues in case-control studies.


The most difficult and most important considerations in planning the protocol of a case-control study are ascertainment of cases, selection of controls and the quality of the exposure measurement. Plans to ensure careful field work are equally important; without attention to data collection, the protocol will be meaningless. In most case-control studies, the measurement problem is magnified because one cannot implement the collection of exposure information at the beginning of follow-up, and instead must rely on interviews, existing records or extrapolation into the past. Consideration of a case-control study as an efficient way to study a cohort helps to resolve some design issues.


Citations per Year

103 Citations

Semantic Scholar estimates that this publication has 103 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wacholder1995DesignII, title={Design issues in case-control studies.}, author={Sholom Wacholder}, journal={Statistical methods in medical research}, year={1995}, volume={4 4}, pages={293-309} }