Design features of a mitotic spindle: balancing tension and compression at a single microtubule kinetochore interface in budding yeast.

Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors in chromosome segregation result in aneuploidy and have severe consequences on human health. Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells. Hence, segregation errors are thought to be a major… CONTINUE READING