Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.

@article{Setti2006DesignAS,
  title={Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.},
  author={Eduardo L. Setti and Shankar Venkatraman and James Trevor Palmer and Xiaoming Xie and Harry Cheung and Walter Yu and Gregg A Wesolowski and J Michael Robichaud},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 16},
  pages={
          4296-9
        }
}
The synthesis and biological profile of a novel series of potent and selective inhibitors of cysteine protease cathepsin K (Cat K) are described. Pharmacokinetic evaluation of 12 indicated that some members of this series could be suitable candidates to develop new orally active therapeutic agents for the treatment of osteoporosis. 
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