Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities.

Abstract

Methylxanthines especially theophylline have been recognized as potent bronchodilators for the relief of acute asthma for over 65 years. Recently, it was found that bacterial infection plays a role in asthma pathogenesis. Accordingly, the present work involves the synthesis of 6-(4-(un)substituted phenyl)thiazolo[2,3-f]theophyllines 2a-g and different… (More)
DOI: 10.1007/s12272-011-0101-8

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