Design and synthesis of simple macrocycles active against vancomycin-resistant enterococci (VRE).

@article{Jia2006DesignAS,
  title={Design and synthesis of simple macrocycles active against vancomycin-resistant enterococci (VRE).},
  author={Yanxing Jia and Nianchun Ma and Zuosheng Liu and Mich{\`e}le Bois-choussy and Eduardo Gonz{\'a}lez-Zamora and Adriano Malabarba and Cristina Brunati and Jieping Zhu},
  journal={Chemistry},
  year={2006},
  volume={12 20},
  pages={
          5334-51
        }
}
16-membered meta,para-cyclophanes mimicking the vancomycin binding pocket (D-O-E ring) were designed and synthesized. The structural key features of these biaryl ether containing macrocycles are (1) the presence of beta-amino-alpha-hydroxy acid or alpha,beta-diamino acid as the C-terminal component of the cyclopeptide and (2) the presence of a hydrophobic chain or lipidated aminoglucose at the appropriate position. Cycloetherification by an intramolecular nucleophilic aromatic substitution… CONTINUE READING
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