Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.

@article{Reddy2011DesignAS,
  title={Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.},
  author={Manoj Kumar C Reddy and Nishant S. Jain and Deepthi Yada and Ch. Nanda Kishore and Janakiram Reddy Vangala and Reddy P Surendra and Anthony Addlagatta and Shasi V Kalivendi and Bojja Hyderabad Sreedhar},
  journal={Journal of medicinal chemistry},
  year={2011},
  volume={54 19},
  pages={
          6751-60
        }
}
A new series of resveratrol analogues was designed, synthesized, and demonstrated to be tubulin polymerization inhibitors. Most of these compounds exhibited antiproliferative activity and inhibited in vitro tubulin polymerization effectively at concentrations of 4.4-68.1 and 17-62 μM, respectively. Flow cytometry studies showed that compounds 7c, 7e, and 7g arrested cells in the G2/M phase of the cell cycle. Immunocytochemistry revealed loss of intact microtubule structure in cells treated with… CONTINUE READING
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