Design and synthesis of pyrazolo[3,4-d]pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma.

@article{Elshaier2017DesignAS,
  title={Design and synthesis of pyrazolo[3,4-d]pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma.},
  author={Yaseen A M M Elshaier and Mohamed A Shaaban and Mohammed K. Abd El Hamid and Mostafa H Abdelrahman and Mahrous A Abou-Salim and Sara M Elgazwi and Fathi T. Halaweish},
  journal={Bioorganic & medicinal chemistry},
  year={2017},
  volume={25 12},
  pages={2956-2970}
}
A new series of pyrazolo[3,4-d]pyrimidines tethered with nitric oxide (NO) producing functionality was designed and synthesized. Sulforhodamine B (SRB) protein assay revealed that NO releasing moiety in the synthesized compounds significantly decreased the cell growth more than the des-NO analogues. Compounds 7C and 7G possessing N-para-substituted phenyl… CONTINUE READING