Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).

Abstract

DAG-lactones afford a synthetically accessible, high affinity platform for probing structure activity relationships at the C1 regulatory domain of protein kinase C (PKC). Given the central role of PKC isoforms in cellular signaling, along with their differential biological activities, a critical objective is the design of isoform selective ligands. Here, we… (More)
DOI: 10.1016/j.ejmech.2014.11.025

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@article{Ann2015DesignAS, title={Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).}, author={Jihyae Ann and Suyoung Yoon and Jisoo Baek and Da hye Kim and Nancy E. Lewin and Colin Hill and Peter M. Blumberg and Jeewoo Lee}, journal={European journal of medicinal chemistry}, year={2015}, volume={90}, pages={332-41} }