Design and synthesis of potent and subtype-selective PPARalpha agonists.

Abstract

Beginning with a moderately potent PPARgamma agonist 9, a series of potent and highly subtype-selective PPARalpha agonists was identified through a systematic SAR study. Based on the results of the efficacy studies in the hamster and dog models of dyslipidemia and the desired pharmacokinetic data, the optimized compound 39 was selected for further profiling… (More)

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@article{Desai2006DesignAS, title={Design and synthesis of potent and subtype-selective PPARalpha agonists.}, author={Ranjit Desai and Edward J Metzger and Conrad Santini and P. Meinke and James V Heck and Joel P. Berger and Karen L Macnaul and Tian-quan Cai and Samuel D. Wright and Arun Agrawal and David E. Moller and Soumya Sahoo}, journal={Bioorganic & medicinal chemistry letters}, year={2006}, volume={16 6}, pages={1673-8} }