Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.

@article{Yu2013DesignAS,
  title={Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.},
  author={Shenghui Yu and Tino Wilson Sanchez and Yang Liu and Yanzhen Yin and Nouri Neamati and Guisen Zhao},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 22},
  pages={6134-7}
}
A series of novel pyrimidone analogues have been designed and synthesized as HIV-1 integrase (IN) inhibitors. This study demonstrated that introducing a substituent in the N1-position of the pyrimidone scaffold does not significantly influence IN inhibitory activity. Molecular docking studies showed these compounds could occupy the IN active site and form pi-pi interactions with viral DNA nucleotides DC16 and DA17 to displace reactive viral DNA 3'OH and block intasome activity.